Formulation Development and Evaluation of Microemulsion Based Lornoxicam Gel
نویسندگان
چکیده
The objective of the existing research was formulation development and preparation microemulsion loaded emulgel in augmenting topical delivery Lornoxicam. Emulsion gel combined are recognized as Emulgels. Gelling agents Carbopol 940, 974, 980 were used to formulating Lornoxicam emulgel. drug release from determined depending on different gelling agents. Clove oil for internal phase Polyethylene glycol 200 applied co-surfactant Tween 20 permeation enhancer. Prepared emulgels evaluated in-vitro in- vivo anti-inflammatory activity using Albino mice stability studies. optimized batch gave better results when compared with marketed Diclofenac sodium gel. 90.42% detected 8 hr. free skin irritation 62.02% inhibition edema. Correspondingly, prepared formulations found be stable. Developed increased solubility drugs, so that less soluble drugs can formulation. (1.5 %) Therefore, microemulsion-loaded Emulgel analgesic effect.
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ژورنال
عنوان ژورنال: Biosciences, Biotechnology Research Asia
سال: 2022
ISSN: ['0973-1245', '2456-2602']
DOI: https://doi.org/10.13005/bbra/2968